Cameron rules out second referendum as sparks fly in Johnson clash

David Cameron derided London mayor Boris Johnson's suggestion that a second referendum on Britain's European Union membership might be possible to secure better terms from Brussels, saying the vote on 23 June will be "final".

An already fraught relationship between the Prime Minister and Johnson only got worse on Monday afternoon after Cameron launched a string of barbs during a speech in the House of Commons.

Cameron attacked the motivations behind Johnson throwing his hat in the ring with the 'Leave' campaign, arguing he might see it as a successful ploy for his own political ambitions.

"I won't dwell on the irony that some people who want to leave in order to remain," Cameron told MPs.

"Such an approach also ignores more profound points about democracy and diplomacy".

"Sadly, Mr Speaker, I have known a number of couples who have begun divorce proceedings. I do not know any who have begun divorce proceedings in order to renew their wedding vows," he added.

In the opinion of the Tory leader - who has previously said he will not stand for re-election - the terms of the agreement reached in Brussels meant the UK would be forever "carved out" of the promise of an 'ever closer union'.

"It means the ratchet of the European court taking power away from this country cannot happen in the future."

Johnson could be seen muttering "rubbish, rubbish" as the Prime Minister spoke and has called on Britons not to heed the fearmongers about the dangers of a Brexit and to be "brave" in their vote.

For London's Mayor, "there is only one way to get the change we need – and that is to vote to go”.