Shire eyes adult ADHD drug application in 2016 after encouraging results

Shire plans to resubmit a new drug application in the US for its potential treatment for adult attention-deficit/hyperactivity disorder (ADHD) after efficacy and safety trials produced positive results.

Tory leadership race starts; Crabb, Javid to run on joint ticket

The first candidates for the Conservative leadership race declared themselves on Wednesday as nominations opened for the successor to Prime Minister David Cameron.

Brammer hits 14-year low after warning on profit, dividend and covenants

Industrial products distributor Brammer has warned it will be close to breaking its debt covenents and is reviewing whether to pay an interim dividend as profits for the year are likely to fall short of expectations.

Lloyds to cut 640 jobs and close 23 branches

Lloyds Banking Group is to cut about 640 jobs and close 23 branches as part of its programme to cut costs and restructure the bank.

Broker tips: Ocado, Prudential, Shawbrook

Shares in Ocado gave up much of Tuesday's gains as further downgrades were made to forecasts for the current year by Barclays and Exane BNP Paribas.

Chemring FD Steve Bowers to step down

Chemring said on Wednesday that finance director Steve Bowers is leaving the defence company to take up the role of chief financial officer at law firm Herbert Smith Freehills.

Sportech gets £93m VAT repayment from HMRC but appeal awaits

Football pools and horse-racing pari-mutuel systems specialist Sportech has potentially hit the jackpot with the UK tax office, taking payment of £93m after winning a seven-year tax battle over its "Spot the Ball" game.

Unemployed? Head to Kaitangata - the New Zealand town with too many jobs

A small town on the south island of New Zealand is looking to outsiders to fix a very good problem for the local community - they have too many jobs. The 800 residents of Kaitangata have launched a drive to recruit new people to move in with attractive house prices.

Clinigen teams up with Horizon on RAVICTI

Clinigen Group was celebrating on Wednesday, as its Idis Managed Access division and Nasdaq-traded Horizon Pharma initiated a Managed Access Programme in Europe for Horizon’s RAVICTI oral liquid.

UK investment to drop 5% next year on Brexit, says Fitch

Investment in the UK economy is likely to fall by 5% next year following the vote to leave the European Union, according to ratings agency Fitch, which downgraded the UK’s credit rating to AA from AA+ earlier this week.

Qannas Investments reports on 'challeging year'

Emerging markets investing company Qannas Investments reported on what it called a “challenging” 2015 calendar year on Wednesday, posting losses of $1. 3m.

Dixons Carphone agrees major US expansion with Sprint after bumper 2016

Profits rose 17% in the year to April at Dixons Carphone, which delivered a updated strategy and an optimistic appraisal of its chances post-Brexit as the largest player in the UK market.

UK auto industry boosted by single market, says SMMT

Access to the single market has made the British car industry one of the most competitive in the world, the trade's industry body said on Wednesday as it reported record turnover last year.

Europe midday: Equity markets rally as Brexit fears subside for now

European stocks rose again on Wednesday as investors put their concerns about Brexit aside to snap up some bargains.

GameAccount Network celebrates Pennsylvania gambling bill

Developer and supplier of enterprise-level B2B internet gaming software GameAccount Network welcomed the approval of a bill by the Pennsylvania House of Representatives on Wednesday.

London midday: Stocks rally on bargain hunting post-Brexit

London stocks rallied on Wednesday as investors took advantage of bargains following Britain’s decision to leave the European Union.

US pre-open: Stocks seen higher again as investors snap up bargains

US futures pointed to another positive session on Wall Street on Wednesday, as investors put Brexit worries aside and continued to pick up some bargains.

UK has the world's fastest mobile internet

Asia report: Markets close higher after 'turnaround Tuesday'

Markets in Asia closed higher on Wednesday, following on from gains in Europe and the US on so-called ‘turnaround Tuesday’ in the wake of the UK’s shock decision to leave the European Union last week.

WPP joins up with Chinese internet services firm

Advertising giant WPP has signed a memorandum of understanding with Chinese internet services firm Tencent to create a social innovation and ideation lab.